Eliprodil prevents expression of the 70 kDa heat shock protein in MK801-injured neurones.
Pharmacol Toxicol
; 79(3): 166-8, 1996 Sep.
Article
en En
| MEDLINE
| ID: mdl-8884877
The present study examined whether eliprodil (SL 82.0715), an N-methyl-D-aspartate (NMDA) receptor antagonist acting on the polyamine sites induced expression of the 70 kDa heat shock protein (HSP70) in the rat brain. Whereas the NMDA channel blocker MK801 consistently induced HSP70 in posterior cingulate and retrosplenial cortices, eliprodil had no such effects even at the highest dose (50 mg/kg, intraperitoneally), supporting the idea that injury to the cerebrocortical neurones by NMDA receptor antagonists is probably related to specific sites of the receptor. Furthermore, eliprodil, given immediately after injection of MK801, blocked the effects of MK801 on HSP70. The result is discussed in terms of high affinity of eliprodil for the sigma receptor.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Maleato de Dizocilpina
/
Antagonistas de Aminoácidos Excitadores
/
Proteínas de Choque Térmico
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Pharmacol Toxicol
Asunto de la revista:
FARMACOLOGIA
/
TOXICOLOGIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Dinamarca