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Eliprodil prevents expression of the 70 kDa heat shock protein in MK801-injured neurones.
Wang, S; Yang, Q; Moller, C J; Sharp, F R; Haglid, K G.
Afiliación
  • Wang S; Institute of Neurobiology, University of Göteborg, Sweden.
Pharmacol Toxicol ; 79(3): 166-8, 1996 Sep.
Article en En | MEDLINE | ID: mdl-8884877
The present study examined whether eliprodil (SL 82.0715), an N-methyl-D-aspartate (NMDA) receptor antagonist acting on the polyamine sites induced expression of the 70 kDa heat shock protein (HSP70) in the rat brain. Whereas the NMDA channel blocker MK801 consistently induced HSP70 in posterior cingulate and retrosplenial cortices, eliprodil had no such effects even at the highest dose (50 mg/kg, intraperitoneally), supporting the idea that injury to the cerebrocortical neurones by NMDA receptor antagonists is probably related to specific sites of the receptor. Furthermore, eliprodil, given immediately after injection of MK801, blocked the effects of MK801 on HSP70. The result is discussed in terms of high affinity of eliprodil for the sigma receptor.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Maleato de Dizocilpina / Antagonistas de Aminoácidos Excitadores / Proteínas de Choque Térmico / Neuronas Límite: Animals Idioma: En Revista: Pharmacol Toxicol Asunto de la revista: FARMACOLOGIA / TOXICOLOGIA Año: 1996 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Dinamarca
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Maleato de Dizocilpina / Antagonistas de Aminoácidos Excitadores / Proteínas de Choque Térmico / Neuronas Límite: Animals Idioma: En Revista: Pharmacol Toxicol Asunto de la revista: FARMACOLOGIA / TOXICOLOGIA Año: 1996 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Dinamarca