Lymphoproliferative disorders in Sotos syndrome: observation of two cases.

Corsello, G; Giuffrè, M; Carcione, A; Cuzto, M L; Piccione, M; Ziino, O

Corsello, G; Giuffrè, M; Carcione, A; Cuzto, M L; Piccione, M; Ziino, O.

Afiliación

Corsello G; Istituto Materno Infantile, Universita di Palermo, Italy.

Am J Med Genet ; 64(4): 588-93, 1996 Sep 06.

Article en En | MEDLINE | ID: mdl-8870927

RESUMEN

Sotos syndrome is included among the overgrowth disorders, most of which have an increased risk of neoplasms. Sotos syndrome does not appear to be related to a specific tumor type, but rather to the development of solid tumors of ectodermal or mesodermal origin in general. We report on two Sotos syndrome patients who developed a non-Hodgkin lymphoma and an acute lymphoblastic leukaemia, respectively. Our experience suggests that there may exist a high frequency of lymphoproliferative disorders in Sotos syndrome, and points out the importance of a long-term follow-up of Sotos syndrome patients, to detect a possible neoplastic evolution.

Asunto(s)

Anomalías Múltiples/genética; Trastornos Linfoproliferativos/complicaciones; Encéfalo/anomalías; Preescolar; Trastornos del Crecimiento/complicaciones; Trastornos del Crecimiento/genética; Humanos; Masculino; Cráneo/anomalías; Síndrome

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anomalías Múltiples / Trastornos Linfoproliferativos Límite: Child, preschool / Humans / Male Idioma: En Revista: Am J Med Genet Año: 1996 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos

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