Effect of argatroban on the formation of artificial thrombus on dogs.
Int J Tissue React
; 17(3): 109-16, 1995.
Article
en En
| MEDLINE
| ID: mdl-8867650
In the present study, we have investigated the effects of a synthetic antithrombin, Argatroban, and an antiplatelet agent. Ticlopidine hydrochloride, on the weight of artificial thrombus. These drugs at various concentrations were added to canine bloods, which were adjusted to 20%, 40% and 60% of haematocrit, and an artificial thrombus was formed using a modification of Chandler's method. Argatroban inhibited the formation of artificial thrombus, and this marked inhibition was observed especially in the experiment using blood with a high value of Ht. On the other hand, Ticlopidine hydrochloride did not inhibit the formation of artificial thrombus. From these results, it becomes clear that the mechanism of inhibitory action of Argatroban on artificial thrombus formation is based on the inhibition of thrombin activity and not on the inhibition of platelet aggregation. In addition, it is suggested that Argatroban inhibits the aggregation of red blood cells in the manner of direct or indirect action.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Pipecólicos
/
Trombosis
Límite:
Animals
Idioma:
En
Revista:
Int J Tissue React
Año:
1995
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Suiza