C4 polymorphism and extended HLA haplotypes in Namibian San and Khoi and in South African Xhosa.
Tissue Antigens
; 47(2): 111-16, 1996 Feb.
Article
en En
| MEDLINE
| ID: mdl-8851723
We studied C4A and C4B polymorphisms and HLA-B and -DR associations in the San, Khoi and Xhosa. C4A and C4B alleles were determined using conventional protein allotyping methods. The C4A*3, C4B*1 haplotype had a high frequency (30-55%) in all populations. The frequency of C4A*3, C4B*Q0 was 7-19%. The C4A*Q0, C4B*1 haplotype was frequent (15%) in the Khoi but very rare in the San (P < 0.001). C4A*12 A*91, C4B*Q0 was frequent in the Xhosa (15%) but rare in the San and Khoi (P < 0.001). Alleles C4A*5 and C4A*6, and the C4B*2 B*92 duplication were only found in the Xhosa. C4A alleles A*4, A*45, A*58, A*12, A*14, A*19 and the C4A*3 A*91 duplication were only found in the San/Khoi population group. In the San, fourteen extended haplotypes were found in a relatively high frequency (2-7%). In the Xhosa, one extended haplotype (B42, C4A*12 A*91, C4B*Q0, DR18) was found in a very high frequency (13%) and was characteristic for this group; five other extended haplotypes were found with a low frequency (< 3%).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos HLA-B
/
Antígenos HLA-DR
/
Complemento C4a
/
Complemento C4b
Límite:
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
Tissue Antigens
Año:
1996
Tipo del documento:
Article
País de afiliación:
Sudáfrica
Pais de publicación:
Reino Unido