Injury produces early rise in lipoprotein lipase activity in rabbit aorta.
Atherosclerosis
; 125(2): 257-66, 1996 Sep 06.
Article
en En
| MEDLINE
| ID: mdl-8842356
The mechanisms following intimal injury predisposing towards atherosclerotic changes have not been fully elucidated. We speculated that a local increase in the enzyme lipoprotein lipase (LPL) might explain a higher susceptibility of the damaged intima to lipid accretion, and so we investigated the effect of balloon endothelial denudation on LPL activity and cholesterol content (LPLa and Cholc, respectively), in aortas from normolipidemic male New Zealand white rabbits. Arteries were obtained from injured and control animals after 2, 6, 8 and 10 weeks to evaluate the shortest period after de-endothelialization necessary to detect LPLa changes. Injury resulted in a 4-fold LPLa rise (P < 0.01), as early as 2 weeks, and the enzymatic activity remained increased throughout the study period. A mild but significant 22% Cholc increase (P < 0.03) was found after 2 weeks of injury, even in this normolipidemic rabbit model. We conclude that physical damage to the intima markedly and soon increases LPLa. This finding might account for the higher lipid accumulation by injured vessels, providing additional support to the hypothesis of LPL as an atherogenic mediator.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aorta
/
Heridas y Lesiones
/
Lipoproteína Lipasa
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Atherosclerosis
Año:
1996
Tipo del documento:
Article
País de afiliación:
Argentina
Pais de publicación:
Irlanda