Study the presence of fibronectin binding protein (FnBp) in tuberculosis (TB) patients by elisa.
J Pak Med Assoc
; 46(1): 5-7, 1996 Jan.
Article
en En
| MEDLINE
| ID: mdl-8830167
Fibronectin-binding protein (FnBp) antigens are a prominent secretory protein of short term culture supernatants of M. tuberculosis and M. bovis (BCG) and is conserved within the genus Mycobacterium. The 30/31 kDa antigen of M. tuberculosis is one of the major secretory molecules and is probably routinely recognised by the host immune system in the early stage of tuberculosis infection. Serum immune complexes, prepared from TB patients and normals, were analysed for the presence of FnBp by ELISA using an anti-30/31 kDa (FnBp) monoclonal antibody (CF8) and by western blotting using Fibronectin-HRP. A significant difference was seen between normals and TB patients (p < 0.05). This test was found to have a specificity of 80% and a positive predictive value of 73%. This is a preliminary finding and the test needs to be evaluated further for its performance on a larger number of confirmed TB patients and controls.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de la Membrana Bacteriana Externa
/
Proteínas Bacterianas
/
Tuberculosis Pulmonar
/
Proteínas Portadoras
/
Adhesinas Bacterianas
/
Mycobacterium tuberculosis
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Pak Med Assoc
Año:
1996
Tipo del documento:
Article
País de afiliación:
Pakistán
Pais de publicación:
Pakistán