Microtubule-active drugs suppress the closure of the permeability transition pore in tumour mitochondria.

Evtodienko, Y V; Teplova, V V; Sidash, S S; Ichas, F; Mazat, J P

Evtodienko, Y V; Teplova, V V; Sidash, S S; Ichas, F; Mazat, J P.

Afiliación

Evtodienko YV; Institute of Theoretical and Experimental Biophysics, Pushchino, Russian Federation.

FEBS Lett ; 393(1): 86-8, 1996 Sep 09.

Article en En | MEDLINE | ID: mdl-8804430

RESUMEN

We report the effects of anticancer drugs, inhibitors of microtubule organisation, on the mitochondrial permeability transition pore (PTP) in Ehrlich ascites tumour cells. Taxol (5-20 microM) and colchicine (100-500 microM) prevented closing of the cyclosporin A-sensitive PTP. No taxol or colchicine effects on oxidative phosphorylation were observed in the range of concentrations used. We suggest that either membrane-bound tubulin per se can be part of PTP and/or the attachment of mitochondria to the microtubular network is essential for PTP regulation. The taxol inhibition of PTP closure, mediated through interaction with the cytoskeleton, sheds new light on the cytotoxic properties of this anticancer drug.

Asunto(s)

Antineoplásicos/farmacología; Calcio/metabolismo; Carcinoma de Ehrlich/metabolismo; Colchicina/farmacología; Membranas Intracelulares/efectos de los fármacos; Mitocondrias/efectos de los fármacos; Paclitaxel/farmacología; Animales; Ciclosporina/farmacología; Membranas Intracelulares/metabolismo; Ratones; Microtúbulos/efectos de los fármacos; Microtúbulos/metabolismo; Mitocondrias/metabolismo; Permeabilidad/efectos de los fármacos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Ehrlich / Colchicina / Calcio / Paclitaxel / Membranas Intracelulares / Mitocondrias / Antineoplásicos Límite: Animals Idioma: En Revista: FEBS Lett Año: 1996 Tipo del documento: Article Pais de publicación: Reino Unido

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