Neonatal pre-ganglionic sympathectomy affects morphometrically defined architecture in rat cerebral arteries.
Acta Physiol Scand
; 157(2): 225-31, 1996 Jun.
Article
en En
| MEDLINE
| ID: mdl-8800363
In order to clarify further the nature of the long-term influence on the cerebral vasculature by the sympathetic nerves, a bilateral cervical pre-ganglionic denervation was performed in 1-week-old rats. Four weeks later, morphometric determinations of the vascular dimensions revealed diminished media cross-sectional areas and luminal radii in the middle cerebral and posterior cerebral arteries, whereas these parameters were unaffected in the basilar artery. In the latter artery, however, a 40% increase in the cross-sectional area of the internal elastic membrane was found. No re-innervation of the denervated ganglia occurred during the course of the experiment. The results suggest that the long-term effect exerted by the sympathetic nerves is associated with the nerve activity, rather than being a true trophic influence.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fibras Autónomas Preganglionares
/
Simpatectomía
/
Arterias Cerebrales
/
Animales Recién Nacidos
Límite:
Animals
Idioma:
En
Revista:
Acta Physiol Scand
Año:
1996
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Reino Unido