Neonatal chronic sympathectomy in normotensive rats affects pial arteries: enhanced stiffness and reduced capacity to dilate.
Acta Physiol Scand
; 157(2): 217-24, 1996 Jun.
Article
en En
| MEDLINE
| ID: mdl-8800362
The functional implication of previously shown effects on pial wall morphology by sympathectomy was tested. Following either ganglionic or pre-ganglionic denervation in 1-week-old rats the passive arterial compliance was reduced in basal cerebral arteries of 20-week-old normotensive, but not of hypertensive animals. The magnitude of the denervation induced stiffness was similar to the alteration seen in spontaneously hypertensive rats when compared with normotensive animals. No difference was seen between the two types of denervation. Following ganglionic sympathectomy in 1-week old normotensive rats-and examined 19 weeks later-the increase in cerebral blood flow (measured with the [14C]butanol sampling technique) induced by high arterial CO2 concentration was attenuated compared with control, whereas basal cerebral blood flow of 20-week-old animals was not different from control. The results indicate a long-term role by the sympathetic nerves not only on vessel wall composition, but also on the regulatory capacity of the cerebral circulation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arterias
/
Simpatectomía
/
Vasodilatación
/
Animales Recién Nacidos
/
Músculo Liso Vascular
Límite:
Animals
Idioma:
En
Revista:
Acta Physiol Scand
Año:
1996
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Reino Unido