Selective role for trkB neurotrophin receptors in rapid modulation of hippocampal synaptic transmission.
Brain Res Mol Brain Res
; 38(2): 300-3, 1996 Jun.
Article
en En
| MEDLINE
| ID: mdl-8793119
Neurotrophins regulate neuronal survival and phenotypic differentiation. Recent evidence also suggests a role in the modulation of synaptic activity. Using neuronal cell cultures from embryonic hippocampus, we previously found that application of brain-derived neurotrophic factor rapidly enhanced synaptic transmission. We now report that application of neurotrophin-4, another ligand for the trkB neurotrophin receptor, was equally effective in enhancing synaptic currents. In contrast, nerve growth factor, neurotrophin-3, basic fibroblast growth factor and epidermal growth factor did not share this action. Our results suggest that activation of trkB receptors plays a selective role in the regulation of synaptic efficacy in the hippocampus.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Factor de Crecimiento Nervioso
/
Transmisión Sináptica
/
Hipocampo
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Brain Res Mol Brain Res
Asunto de la revista:
BIOLOGIA MOLECULAR
/
CEREBRO
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Países Bajos