[Reduction of lipoproteins with apoAI but without apoAII (LpAI) in non-insulin-dependent diabetic patients]. / Réduction des lipoprotéines avec apoAI mais sans apoAII (LpAI) chez les diabétiques non insulino-dépendants.
Ann Biol Clin (Paris)
; 54(2): 83-6, 1996.
Article
en Fr
| MEDLINE
| ID: mdl-8763631
Recent data suggest the existence of a relationship between ischemic heart diseases and apolipoprotein A-I containing lipoproteins. The latter and other classic lipid-lipo-protein-apoprotein parameters were quantified in 25 non-insulin-dependent diabetics and 26 normoglycemic normolipidemic subjects. Compared to a control group, non-insulin-dependent diabetics have higher levels of plasma cholesterol (p < 0.05), triacylglycerol, apolipoprotein B (p < 0.001). In contrast, their lipoprotein particles containing only apolipoprotein AI without apolipoprotein AII and apoAI/apoB ratio were lowered (p < 0.001). In our diabetics, apolipoprotein AI was found at normal level but its distribution between high density lipoproteins ('HDL') and 'non-HDL' was abnormal. Also, the distribution of particles containing apolipoprotein A-I without apolipoprotein A-II in non-insulin-dependent diabetics was found abnormal. A higher proportion of both apoAI and LpAI were found in the 'non-HDL' fraction. These data show that lipoprotein metabolism is affected in non-insulin-dependent diabete mellitus. The disease is associated to a lipoprotein profile which is in favour of the atherogenic process.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Apolipoproteína A-I
/
Diabetes Mellitus Tipo 2
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Fr
Revista:
Ann Biol Clin (Paris)
Año:
1996
Tipo del documento:
Article
País de afiliación:
Túnez
Pais de publicación:
Francia