Elevated alpha-fetoprotein and human chorionic gonadotropin as a marker for placental trisomy 16 in the second trimester?
Prenat Diagn
; 15(12): 1121-4, 1995 Dec.
Article
en En
| MEDLINE
| ID: mdl-8750291
In a series of 2961 consecutive cases with second-trimester biochemical triple screening for Down's syndrome and neural tube defect (NTD), ten (0.3 per cent) showed an apparent increased risk for both conditions. Three cases had chromosomal abnormalities, namely trisomy 16 confined to the placenta. Since placental trisomy 16 as well as cases with increased alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG) are associated with (intrauterine growth retardation (IUGR), oligohydramnios, and fetal demise, at least some cases with this atypical biochemical profile could be explained by this chromosomal abnormality. From our results we recommend that in cases with increased risk for both Down's syndrome and NTD, fetal karyotyping should preferably be done on a placental biopsy, especially when ultrasound in the absence of anomalies demonstrates early IUGR.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Placenta
/
Diagnóstico Prenatal
/
Trisomía
/
Cromosomas Humanos Par 16
/
Alfa-Fetoproteínas
/
Gonadotropina Coriónica
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Prenat Diagn
Año:
1995
Tipo del documento:
Article
País de afiliación:
Suiza
Pais de publicación:
Reino Unido