New analgesics derived from the phencyclidine analogue thienylcyclidine.

al-Deeb, O A

al-Deeb, O A.

Afiliación

al-Deeb OA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Arzneimittelforschung ; 46(5): 505-8, 1996 May.

Article en En | MEDLINE | ID: mdl-8737636

RESUMEN

Several derivatives of thienylcyclidine (1-[1-(2-thienyl)cyclohexyl]piperidine, CAS 1867-65-8, TCP) were synthesized and characterized. The compounds were evaluated for analgesic agonism in mice using tail-flick test as a model for antinociceptive activity. The most potent compounds are 7 and 11, which are about twice as active as the standard pethidine. The influence of naloxone on the antinociceptive activity of these compounds is also reported. The present pharmacological data are discussed and compared with those previously reported for structurally related phencyclidine analgesics.

Asunto(s)

Analgésicos/farmacología; Fenciclidina/análogos & derivados; Analgésicos/síntesis química; Analgésicos Opioides/farmacología; Animales; Masculino; Meperidina/antagonistas & inhibidores; Meperidina/farmacología; Ratones; Naloxona/farmacología; Antagonistas de Narcóticos/farmacología; Dimensión del Dolor/efectos de los fármacos; Fenciclidina/antagonistas & inhibidores; Fenciclidina/síntesis química; Fenciclidina/farmacología; Tiempo de Reacción/efectos de los fármacos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenciclidina / Analgésicos Límite: Animals Idioma: En Revista: Arzneimittelforschung Año: 1996 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Alemania

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