Progesterone receptors: expression and regulation in the mammalian ovary.
Clin Obstet Gynecol
; 39(2): 424-35, 1996 Jun.
Article
en En
| MEDLINE
| ID: mdl-8734007
ABSTRACT
PIP: Research into the structure, function, expression, and regulation of progesterone receptors (PRs) in the mammalian ovary has the potential to refine understanding of ovulatory processes. A consistent finding of animal studies is the periovulatory expression of the PR gene in the granulosa cells of preovulatory follicles. The presence of PRs in these follicles in the transition from the preovulatory to periovulatory periods may be crucial to successful ovulation given the finding that the blockage of progesterone action at the level of the ovary substantially decreases ovulation rates in hamsters and rats. Estrogen is the primary regulator of PR gene expression in uterine epithelial cells, but not in the ovary. On the other hand, estrogen action is important for preparing granulosa cells for gonadotropin induction of PR gene expression. This cell-specific pattern of gonadotropins/membrane receptor-mediated PR induction in the ovary and estrogen/nuclear receptor mediation in the uterus and mammary gland requires further study. Also needed are studies to determine the identity of PR-regulated target genes during the periovulatory period. The overall thrust of the existing literature, however, indicates that PRs are an essential component of the ovulatory process.
Palabras clave
Animals, Laboratory; Biology; Clinical Research; Cytologic Effects; Decidual Cell Reaction; Endocrine System; Genitalia; Genitalia, Female; Hormone Antagonists; Hormone Receptors; Hormones; Literature Review; Membrane Proteins; Ovarian Effects; Ovary; Ovulation; Physiology; Progestational Hormones; Progesterone; Reproduction; Research Methodology; Urogenital System
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ovario
/
Receptores de Progesterona
/
Regulación de la Expresión Génica
/
Mamíferos
Límite:
Animals
Idioma:
En
Revista:
Clin Obstet Gynecol
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos