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Apoptosis and c-Jun in the thalamus of the rat following cortical infarction.
Soriano, M A; Ferrer, I; Rodríguez-Farré, E; Planas, A M.
Afiliación
  • Soriano MA; Department de Farmacologia i Toxicologia, CID-CSIC, Hospital Prínceps d'Espanya, Universitat de Barcelona, Spain.
Neuroreport ; 7(2): 425-8, 1996 Jan 31.
Article en En | MEDLINE | ID: mdl-8730797
Cortical infarction produces secondary neuronal damage in the thalamus. In this study we examined the thalamus of the rat following 2 h occlusion of the middle cerebral artery (MCA), and found degeneration and gliosis in the ipsilateral ventropostero-medial thalamic nucleus in those rats that showed cortical infarction 7 and 14 days after occlusion. This was accompanied by isolated cells with fragmented DNA, as revealed by in situ labelling of nuclear DNA fragmentation, and showing morphological features of apoptosis, i.e. chromatin condensation, extreme nuclear shrinkage and apoptotic bodies. In addition, cells immunoreactive for c-Jun showing morphological signs of apoptosis were observed. These results provide evidence of apoptosis in the ipsilateral thalamus following cortical infarction, and suggest that c-Jun is involved in this process.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tálamo / Infarto Cerebral / Proteínas Proto-Oncogénicas c-jun / Apoptosis Límite: Animals Idioma: En Revista: Neuroreport Asunto de la revista: NEUROLOGIA Año: 1996 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tálamo / Infarto Cerebral / Proteínas Proto-Oncogénicas c-jun / Apoptosis Límite: Animals Idioma: En Revista: Neuroreport Asunto de la revista: NEUROLOGIA Año: 1996 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido