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A new bell-shaped function for idiotypic interactions based on cross-linking.
De Boer, R J; Boerlijst, M C; Sulzer, B; Perelson, A S.
Afiliación
  • De Boer RJ; Theoretical Biology, Utrecht University, Netherlands. rdb@alive.biol.ruu.nl
Bull Math Biol ; 58(2): 285-312, 1996 Mar.
Article en En | MEDLINE | ID: mdl-8713661
Most recent models of the immune network are based upon a phenomenological log bell-shaped interaction function. This function depends on a single parameter, the "field," which is the sum of all ligand concentrations weighted by their respective affinities. The typical behavior of these models is dominated by percolation, a phenomenon in which a local stimulus spreads globally throughout the network. The usual reason for employing a log bell-shaped interaction function is that B cells are activated by cross-linking of their surface immunoglobulin receptors. Here we formally derive a new phenomenological log bell-shaped function from the chemistry of receptor cross-linking by bivalent ligand. Specifying how this new function depends on the ligand concentrations requires two fields: a binding field and a cross-linking field. When we compare the activation functions for ligand-receptor pairs with different affinities, the one-field and the two-field functions differ markedly. In the case of the one-field activation function, its graph is shifted to increasingly higher concentration as the affinity decreases but keeps its width and height. In the case of the two-field activation function, the graph of a low-affinity interaction is nested within the graphs of all higher-affinity interactions. We show that this difference in the relations among activation functions for different affinities radically changes the network behavior. In models that described B cell proliferation using the one-field activation function, network behavior was dominated by low-affinity interactions. Conversely, in our new model, the high-affinity interactions are the most significant. As a consequence, percolation is no longer the only typical network behavior.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Receptores Inmunológicos / Modelos Inmunológicos / Idiotipos de Inmunoglobulinas Tipo de estudio: Qualitative_research Límite: Animals / Humans Idioma: En Revista: Bull Math Biol Año: 1996 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Receptores Inmunológicos / Modelos Inmunológicos / Idiotipos de Inmunoglobulinas Tipo de estudio: Qualitative_research Límite: Animals / Humans Idioma: En Revista: Bull Math Biol Año: 1996 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos