Determination of synthetic estrogens in illegal veterinary formulations by HPTLC and HPLC.

Nascimento, E S; Salvadori, M C; Ribeiro-Neto, L M

Nascimento, E S; Salvadori, M C; Ribeiro-Neto, L M.

Afiliación

Nascimento ES; Departmento de Análises Clínicas e Toxicology, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo.

J Chromatogr Sci ; 34(7): 330-3, 1996 Jul.

Article en En | MEDLINE | ID: mdl-8675551

RESUMEN

To determine the actual amount of diethylstilbestrol, hexestrol, and dienestrol in formulations such as pellets and oily injections that are illegally available on the Brazilian market, a simple methanol extraction is used for the analysis of the pellets and an ether extraction with Sephadex columns (for clean-up) is used for the oily injections. High-performance thin-layer chromatography is used for identification (as a qualitative and semiquantitative method), and high-performance liquid chromatography is used for quantitation. The results of the analysis show that all the formulations are not in accordance with the information listed on their labels.

Asunto(s)

Cromatografía Líquida de Alta Presión/métodos; Congéneres del Estradiol/análisis; Medicina Veterinaria; Animales; Brasil; Cromatografía Líquida de Alta Presión/estadística & datos numéricos; Dienestrol/análisis; Dietilestilbestrol/análisis; Etiquetado de Medicamentos; Hexestrol/análisis; Drogas Ilícitas/análisis; Legislación de Medicamentos

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicina Veterinaria / Cromatografía Líquida de Alta Presión / Congéneres del Estradiol Tipo de estudio: Qualitative_research Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Chromatogr Sci Año: 1996 Tipo del documento: Article Pais de publicación: Estados Unidos

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links