Genetic characterization and phylogeny of Sabiá virus, an emergent pathogen in Brazil.
Virology
; 221(2): 318-24, 1996 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-8661442
Sabiá virus, one of five arenaviruses from South America known to cause hemorrhagic fever in humans, emerged in 1990 when it was isolated from a fatal case in Sao Paulo, Brazil. Subsequently, it has caused two laboratory-acquired infections. Its natural distribution and host are still unknown. Using viral RNA and multiple polymerase chain reaction products as templates, the nucleotide sequence of the small (S) RNA segment of Sabiá virus, which codes for the nucleocapsid (N) and glycoprotein precursor, was determined. This virus shares an ambisense genome in common with other arenaviruses, although it has a unique predicted three stem--loop structure in the S RNA intergenic region. Phylogenetic analysis of a portion of the N gene sequence confirmed that Sabiá virus is distinct from all other members of the Arenaviridae and shares a progenitor with Junin, Machupo, Tacaribe, and Guanarito viruses.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arenavirus del Nuevo Mundo
/
Fiebre Hemorrágica Americana
Límite:
Animals
/
Humans
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Virology
Año:
1996
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Estados Unidos