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Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor.
Galcheva-Gargova, Z; Konstantinov, K N; Wu, I H; Klier, F G; Barrett, T; Davis, R J.
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  • Galcheva-Gargova Z; Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, 01605, USA.
Science ; 272(5269): 1797-802, 1996 Jun 21.
Article en En | MEDLINE | ID: mdl-8650580
ZPR1 is a zinc finger protein that binds to the cytoplasmic tyrosine kinase domain of the epidermal growth factor receptor (EGFR). Deletion analysis demonstrated that this binding interaction is mediated by the zinc fingers of ZPR1 and subdomains X and XI of the EGFR tyrosine kinase. Treatment of mammalian cells with EGF caused decreased binding of ZPR1 to the EGFR and the accumulation of ZPR1 in the nucleus. The effect of EGF to regulate ZPR1 binding is dependent on tyrosine phosphorylation of the EGFR. ZPR1 therefore represents a prototype for a class of molecule that binds to the EGFR and is released from the receptor after activation.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Portadoras / Dedos de Zinc / Receptores ErbB Límite: Animals / Humans / Male Idioma: En Revista: Science Año: 1996 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Portadoras / Dedos de Zinc / Receptores ErbB Límite: Animals / Humans / Male Idioma: En Revista: Science Año: 1996 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos