[Correlation between osteocalcin and bone histomorphometry in children with chronic renal failure]. / Zaleznosc miedzy osteokalcyna a wskaznikami histomorfometrycznymi kosci u dzieci z przewlekla niewydolnoscia nerek.
Pediatr Pol
; 70(12): 1011-5, 1995 Dec.
Article
en Pl
| MEDLINE
| ID: mdl-8649939
The study was performed in 17 children with chronic renal failure, 7 were on hemodialysis, 6 on continuous ambulatory peritoneal dialysis, 4 were treated conservatively. In all, serum levels of alkaline phosphatase, PTH intact and osteocalcin were measured and bone biopsy was performed. We analyzed correlations between biochemical markers of bone metabolism and histomorphometric parameters. The lowest mean serum osteocalcin levels were found in children with adynamic bone disease, the highest with osteitis fibrosa. The serum osteocalcin level was significantly correlated with the dynamic parameter of bone formation rate (BFR), which suggests that this biochemical marker can be of use in discriminating between renal osteopathy with low and high bone turnover. Lack of correlation between serum osteocalcin level and mineralizing surface confirms it significance as a good marker of osteoblastic activity in bone formation but not in bone mineralization.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastorno Mineral y Óseo Asociado a la Enfermedad Renal Crónica
/
Huesos
/
Osteocalcina
/
Fallo Renal Crónico
Límite:
Child
/
Humans
Idioma:
Pl
Revista:
Pediatr Pol
Año:
1995
Tipo del documento:
Article
Pais de publicación:
Polonia