Evidence for an inducible repair-recombination system in the female germ line of Drosophila melanogaster. I. Induction by inhibitors of nucleotide synthesis and by gamma rays.
Genetics
; 141(2): 571-8, 1995 Oct.
Article
en En
| MEDLINE
| ID: mdl-8647393
In the I-R system of hybrid dysgenesis in Drosophila melanogaster, the transposition frequency of I factor, a LINE element-like retrotransposon, is regulated by the reactivity level of the R mother. This reactivity is a cellular state maternally inherited but chromosomally determined, which has been shown to undergo heritable, cumulative and reversible changes with aging and some environmental conditions. We propose the hypothesis that this reactivity level is one manifestation of an inducible repair-recombination system whose biological role might be analogous to the SOS response in bacteria. In this paper, we show that inhibitors of DNA synthesis and gamma rays enhance the reactivity level in a very similar way. This enhancement is heritable, cumulative and reversible.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Recombinación Genética
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Uracilo
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Metotrexato
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Reparación del ADN
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Drosophila melanogaster
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Antimetabolitos
Límite:
Animals
Idioma:
En
Revista:
Genetics
Año:
1995
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Estados Unidos