A Herpes saimiri oncogene causing peripheral T-cell lymphoma in transgenic mice.
Oncogene
; 12(8): 1609-16, 1996 Apr 18.
Article
en En
| MEDLINE
| ID: mdl-8622880
Herpesvirus saimiri is an oncogenic virus causing rapid T-cell lymphomas in New World primates and rabbits. Deletion analysis of one strain of H saimiri has indicated an open reading frame, StpA, necessary for oncongenicity in monkeys. We have investigated the function of StpA in tumor induction by the generation of transgenic mice. Expression of two different constructs caused the development of peripheral lymphomas. The infiltrating cells were of T-cell origin, expressing mainly the CD4 phenotype and restricted sets of V beta chains. Thus, StpA is not only necessary for the oncogenicity of Herpesvirus saimiri, but is also sufficient for the induction of peripheral pleomorphic T-cell lymphomas.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Ratones Transgénicos
/
Proteínas Oncogénicas Virales
/
Linfoma de Células T
/
Herpesvirus Saimiriino 2
/
Chaperonas Moleculares
/
Proteínas de Escherichia coli
/
Proteínas de Unión al ADN
Límite:
Animals
Idioma:
En
Revista:
Oncogene
Asunto de la revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Año:
1996
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Reino Unido