Gestodene-containing contraceptives.
Clin Obstet Gynecol
; 38(4): 829-40, 1995 Dec.
Article
en En
| MEDLINE
| ID: mdl-8616979
ABSTRACT
PIP: Gestodene (GSD) is the most potent and therefore lowest dosed progestogen used in oral contraceptives. Pharmacokinetic studies have found serum levels of GSD to be considerably higher than those of comparable progestogens taken at higher doses. The monophasic and triphasic formulation suppress gonadotropin release and ovarian function profoundly and inhibit ovulation reliably, with GSD's strong anti-estrogenic and progestogenic effectiveness based upon the high GSD serum concentrations achieved during daily intake. The authors describe the pharmacologic properties of GSD, formulations containing GSD and ethinyl estradiol, pharmacokinetics, contraceptive effectiveness, cycle control and side effects, the effect on hormonal parameters, the effect on lipid metabolism, the effect on carbohydrate metabolism, and the effect on hemostasis.
Palabras clave
Biology; Blood Coagulation Effects; Carbohydrate Metabolic Effects; Contraception; Contraceptive Agents, Female--pharmacodynamics; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--pharmacodynamics; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--pharmacodynamics; Contraceptive Agents--side effects; Contraceptive Effectiveness; Contraceptive Methods; Endocrine Effects; Endocrine System; Family Planning; Gestodene--pharmacodynamics; Gestodene--side effects; Hematological Effects; Hemic System; Lipid Metabolic Effects; Lipids; Literature Review; Metabolic Effects; Oral Contraceptives; Physiology
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anticonceptivos Sintéticos Orales
/
Congéneres de la Progesterona
/
Norpregnenos
Límite:
Female
/
Humans
Idioma:
En
Revista:
Clin Obstet Gynecol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Estados Unidos