Your browser doesn't support javascript.
loading
A comparative analysis of the photosensitized inhibition of growth-factor regulated protein kinases by hypericin-derivatives.
Agostinis, P; Donella-Deana, A; Cuveele, J; Vandenbogaerde, A; Sarno, S; Merlevede, W; de Witte, P.
Afiliación
  • Agostinis P; Afdeling Biochemie, Faculteit der Geneeskunde, Katholieke Universiteit, Leuven, Belgium.
Biochem Biophys Res Commun ; 220(3): 613-7, 1996 Mar 27.
Article en En | MEDLINE | ID: mdl-8607812
The photodynamic inhibitory effect of hypericin and a number of hypericin-derivatives were investigated in vitro using numerous growth-factor regulated protein kinases including receptor-bound (Insulin-R, EGF-R) and non-receptor (Lyn, c-Fgr, CSK, Syk) protein tyrosine kinases as well as Ser/Thr (PK-C, protein kinase CK-2, CK-1) protein kinases. Modification of the hypericin structure altered significantly the specificity of the protein kinase inhibition. In particular, methylation or attachment of long lipophilic chains to both methyl groups of the hypericin molecule strongly enhanced the specificity toward PK-C.
Asunto(s)
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Perileno / Sustancias de Crecimiento / Fármacos Fotosensibilizantes / Inhibidores de Proteínas Quinasas / Inhibidores Enzimáticos Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 1996 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Perileno / Sustancias de Crecimiento / Fármacos Fotosensibilizantes / Inhibidores de Proteínas Quinasas / Inhibidores Enzimáticos Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 1996 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos