A case of autoimmune hemolytic anemia induced by IFN-beta therapy for type-C chronic hepatitis.

Kazuta, Y; Watanabe, N; Sagawa, K; Kobayashi, H; Kojima, T; Funabashi, H; Moritoh, T; Kasukawa, R

Kazuta, Y; Watanabe, N; Sagawa, K; Kobayashi, H; Kojima, T; Funabashi, H; Moritoh, T; Kasukawa, R.

Afiliación

Kazuta Y; Department of Internal Medicine, Hanawa Kohsei Hospital, Fukushima, Japan.

Fukushima J Med Sci ; 41(1): 43-9, 1995 Jun.

Article en En | MEDLINE | ID: mdl-8606041

RESUMEN

A 51-year old woman who had type-C chronic hepatitis developed autoimmune hemolytic anemia after 4 weeks treatment with a total 48 million interferon-beta, 6 million 8 times. Indirect Coomb's test turned from negative to positive through IFN therapy and a complication of asymptomatic primary biliary cirrhosis was confirmed by histologic findings of the biopsied liver which was performed during IFN therapy and a presence of anti-mitochondrial antibody. After stopping IFN therapy and adding prednisolone anemia improved in getting negative indirect Coombs test but remaining positive direct Coombs test.

Asunto(s)

Anemia Hemolítica Autoinmune/etiología; Hepatitis C/terapia; Interferón beta/efectos adversos; Femenino; Humanos; Persona de Mediana Edad

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interferón beta / Hepatitis C / Anemia Hemolítica Autoinmune Límite: Female / Humans / Middle aged Idioma: En Revista: Fukushima J Med Sci Año: 1995 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón

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