Effects of perinatal vaccination on humoral and cellular immune responses in cows and young calves.
J Am Vet Med Assoc
; 208(3): 393-400, 1996 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-8575972
OBJECTIVE: To examine the effects of perinatal vaccination on cellular and humoral responses in cows and on passive transfer of antibodies and cells to calves, and to assess the role of maternal antibodies in vaccination responses of neonatal calves. DESIGN: Prospective randomized control trial. ANIMALS: 52 beef cows and their calves. PROCEDURES: Assigned cows were vaccinated twice during the last month of gestation. Assigned calves were vaccinated at day 10 after birth. Antibody concentrations and cellular responses to bovine respiratory syncytial virus (BRSV) and bovine herpesvirus type 1 (BHV-1) were measured in blood and colostrum of cows and in blood of calves. Calves were assessed for passive transfer of lymphocytes. RESULTS: At parturition, serum antibody concentrations to BRSV as well as BHV-1- and BRSV-specific blastogenic responses were significantly higher in vaccinated cows. After birth, calves from vaccinated cows had significantly higher concentrations of BRSV-specific serum antibodies, but not BHV-1 specific antibodies. Calves did not develop delayed-type hypersensitivity responses to BRSV. At weaning, lymphocytes from neonatally vaccinated calves had significantly higher values for virus-specific proliferation than did lymphocytes from unvaccinated calves; however, significant differences were not detected between groups after vaccination at weaning. CLINICAL IMPLICATIONS: Administration of modified-live viral vaccines can boost systemic humoral and cellular responses to BRSV and BHV-1 in cows. Neonatal calves can be immunologically primed by vaccination with modified-live virus vaccines. Virus-specific memory cells persist in most calves until weaning.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bovinos
/
Vacunación
/
Virus Sincitial Respiratorio Bovino
/
Herpesvirus Bovino 1
/
Inmunidad Materno-Adquirida
/
Animales Recién Nacidos
/
Anticuerpos Antivirales
Tipo de estudio:
Observational_studies
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Am Vet Med Assoc
Año:
1996
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos