Changes in EEG power density of non-REM sleep in depressed patients during treatment with trazodone.
J Affect Disord
; 35(1-2): 11-9, 1995 Oct 09.
Article
en En
| MEDLINE
| ID: mdl-8557883
Recently, it was hypothesized that acute or cumulative suppression of non-REM sleep intensity might be related to the therapeutic effects of antidepressants. This intensity has been proposed to be expressed in the EEG power density in non-REM sleep. In the present study, the relationship was examined between the changes of EEG power density in non-REM sleep and the changes in clinical state in 8 depressed patients during treatment with trazodone. A 1-week wash-out period was followed by 1 week of placebo administration, a medication period of 5 weeks and a 1-week placebo period. To minimize systematic influences of sleep duration and non-REM-REM sleep alterations, EEG power was measured over the longest common amount of non-REM sleep stages 2-4 (168.5 min), accumulated from sleep onset onwards. During trazodone treatment, the 13- and 14-Hz bins showed a significant reduction in EEG power. No clear-cut change, however, was observed in the EEG power of the delta frequency range (1-4 Hz) which is considered to be the principle manifestation of non-REM sleep intensity. Furthermore, no overall significant relationship between EEG power suppression and clinical improvement could be demonstrated.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fases del Sueño
/
Trazodona
/
Polisomnografía
/
Antidepresivos de Segunda Generación
/
Trastorno Depresivo
/
Electroencefalografía
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Affect Disord
Año:
1995
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Países Bajos