Growth in stature in fragile X families: a mixed longitudinal study.
Am J Med Genet
; 58(3): 249-56, 1995 Sep 11.
Article
en En
| MEDLINE
| ID: mdl-8533827
The effect of fragile X on growth in stature was estimated in individuals aged 5-20 years from 50 fragile X families. The multivariate normal model for pedigree analysis was applied to the mixed longitudinal data, which varied with regard to intervals between the measurements and their number in individual subjects, totalling 349 measurement data points from fragile X families, and 292 data points from unrelated normal subjects. The results of genetic and regression analysis showed that, in fragile X boys and girls, total pubertal height gain is impaired, whereas the rate of growth during the preadolescent period is increased, compared with the growth rate of nonfragile X subjects. Moreover, the growth parameters in fragile X males were found to be correlated with the size of CGG trinucleotide expansion. The hypothesis of premature activation of the hypothalamo-pituitary gonadal axis is postulated as the cause of growth impairment in fragile X boys and girls, which should be verified by data on the timing of pubertal stages, hormone levels, and bone maturation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome del Cromosoma X Frágil
/
Trastornos del Crecimiento
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Child
/
Female
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Humans
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Male
Idioma:
En
Revista:
Am J Med Genet
Año:
1995
Tipo del documento:
Article
País de afiliación:
Australia
Pais de publicación:
Estados Unidos