[Clinical effectiveness of Marvelon]. / Analiza kliniczna stosowania Marvelonu.
Ginekol Pol
; 66(5): 294-6, 1995 May.
Article
en Pl
| MEDLINE
| ID: mdl-8522228
ABSTRACT
PIP: Marvelon is an oral contraceptive of the third generation of contraceptives introduced in the 1980s. These preparations contain progestagens (desogestrel, gestodene, and norgestimate) and ethinyl estradiol. Marvelon contains .03 mg of ethinyl estradiol and .15 mg of desogestrel. The results of clinical use of Marvelon (made by Organon), were studied in 32 women aged 30 +or- 5 years in the course of at least six cycles. Marvelon was well tolerated and the subjective side effects were minor. The cycles were regular and withdrawal bleeding lasted 3-5 days. The duration of menstrual cycles with the use of Marvelon constituted 27-30 days. The amount of bleeding did not change in 26 women, while it became less in 6 women. Marvelon did not affect body weight and blood pressure. The weight of the patients varied within the limit of +or- 2 kg. It produced a favorable lipid profile by increasing the mean level of high density lipoprotein (HDL) cholesterol and lowering the mean level of low density lipoprotein (LDL) cholesterol. The level of HDL cholesterol was 1.56 mmol/l in cycle 0 compared with 1.85 in cycle 6. The average level of LDL cholesterol was statistically lower in the 6th cycle of Marvelon use (2.73 mmol/l) in comparison to cycle 0 (3.29 mmol/l). Marvelon did not significantly influence the values of glucose, total cholesterol, and triglycerides. The Pearl Index was 0.0.
Palabras clave
Biology; Cholesterol; Clinical Research; Clinical Trials; Contraception; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--side effects; Contraceptive Effectiveness; Contraceptive Methods--side effects; Desogestrel--side effects; Developed Countries; Eastern Europe; Europe; Family Planning; Gestodene--side effects; Lipid Metabolic Effects; Lipids; Norgestimate--side effects; Oral Contraceptives, Combined--side effects; Oral Contraceptives, Low-dose--side effects; Oral Contraceptives--side effects; Physiology; Poland; Research Methodology
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Desogestrel
/
Anticonceptivos Sintéticos Orales
Límite:
Adult
/
Female
/
Humans
Idioma:
Pl
Revista:
Ginekol Pol
Año:
1995
Tipo del documento:
Article
Pais de publicación:
Polonia