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A vaccinia-vectored rabies vaccine field trial: ante- and post-mortem biomarkers.
Hanlon, C A; Buchanan, J R; Nelson, E; Niu, H S; Diehl, D; Rupprecht, C E.
Afiliación
  • Hanlon CA; Thomas Jefferson University, Department of Microbiology and Immunology, Philadelphia, PA 19107.
Rev Sci Tech ; 12(1): 99-107, 1993 Mar.
Article en En | MEDLINE | ID: mdl-8518451
During the field safety evaluation of a vaccinia-rabies glycoprotein recombinant virus vaccine for wildlife, two biomarkers were used to identify potential contact with vaccine-laden baits. Tetracycline, a commonly used and reliable calciphilic tissue marker, was included in a fish-meal polymer bait matrix and was evaluated from post-mortem bone samples. Additionally, an ante-mortem marker was needed to identify, for prospective study, raccoons which had contacted baits and thus, potentially, vaccine. Sulfadimethoxine (SDM) was included in an attractant slurry surrounding the bait, as a novel short-term seromarker. Preliminary laboratory studies in raccoons demonstrated SDM residues for up to one week following ingestion of a single 250 mg dose. During the first six days after bait distribution, 49 individual raccoons were live-trapped in the vaccination area. SDM was detectable in 38 of 49 (77.5%) serum samples. Similarly, 47 of 56 (83.9%) bone samples from raccoons collected in the vaccination area throughout the twelve-month study were tetracycline-positive. Conversely, none of the serum samples (n = 12) from the first six days of the trial nor any of the bone samples (n = 34) from raccoons in the surveillance area were biomarker-positive.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mapaches / Vacunas Antirrábicas / Biomarcadores / Vacunación / Animales Salvajes Tipo de estudio: Observational_studies Límite: Animals País/Región como asunto: America do norte Idioma: En Revista: Rev Sci Tech Asunto de la revista: DOENCAS TRANSMISSIVEIS / MEDICINA VETERINARIA Año: 1993 Tipo del documento: Article Pais de publicación: Francia
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mapaches / Vacunas Antirrábicas / Biomarcadores / Vacunación / Animales Salvajes Tipo de estudio: Observational_studies Límite: Animals País/Región como asunto: America do norte Idioma: En Revista: Rev Sci Tech Asunto de la revista: DOENCAS TRANSMISSIVEIS / MEDICINA VETERINARIA Año: 1993 Tipo del documento: Article Pais de publicación: Francia