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Reoxygenation following hypoxia stimulates lipid peroxidation and phosphatidylinositol breakdown in kidney cortical slices.
Cotterill, L A; Gower, J D; Clark, P K; Fuller, B J; Thorniley, M S; Goddard, J G; Green, C J.
Afiliación
  • Cotterill LA; Section of Surgical Research, Clinical Research Centre, Harrow, Middlesex, U.K.
Biochem Pharmacol ; 45(10): 1947-51, 1993 May 25.
Article en En | MEDLINE | ID: mdl-8512580
Reoxygenation of hypoxic (120 min at 37 degrees) rabbit kidney cortical slices in vitro resulted in a rapid increase in lipid peroxidation and phosphatidylinositol hydrolysis. No changes in phosphatidylinositol breakdown occurred during hypoxia or upon reoxygenation in the absence of calcium. Incubation of renal slices with carbon tetrachloride resulted in increased lipid peroxidation but had no effect on phosphatidylinositol breakdown. It is concluded that altered intracellular calcium homeostasis during reoxygenation is involved in mediating increased phosphatidylinositol hydrolysis through activation of a specific phospholipase C, but that oxidative stress per se does not have a significant effect on the inositol phosphate secondary messenger response in this model system.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Fosfatidilinositoles / Peroxidación de Lípido / Hipoxia de la Célula / Corteza Renal Límite: Animals Idioma: En Revista: Biochem Pharmacol Año: 1993 Tipo del documento: Article Pais de publicación: Reino Unido
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxígeno / Fosfatidilinositoles / Peroxidación de Lípido / Hipoxia de la Célula / Corteza Renal Límite: Animals Idioma: En Revista: Biochem Pharmacol Año: 1993 Tipo del documento: Article Pais de publicación: Reino Unido