Effects of luteinizing hormone-releasing hormone analogue on DNA synthesis in rat prostate and uterus.

Sakamoto, S; Tajima, M; Sawaki, K; Suzuki, S; Kudo, H; Sassa, S; Kuwa, K; Sugiura, Y; Kasahara, N; Nagasawa, H

Sakamoto, S; Tajima, M; Sawaki, K; Suzuki, S; Kudo, H; Sassa, S; Kuwa, K; Sugiura, Y; Kasahara, N; Nagasawa, H.

Afiliación

Sakamoto S; Medical Research Institute, Tokyo Medical and Dental University, Japan.

In Vivo ; 7(1): 13-6, 1993.

Article en En | MEDLINE | ID: mdl-8504203

RESUMEN

Buserelin, a potent LH-RH agonist, has been used for the treatment of hormonal disorders such as precocious puberty, endometriosis, cystic mastitis and prostatic carcinoma. Prolonged treatment with buserelin has been known to induce a refractory phase of pituitary desensitization. In the present study, we found that two-week treatment with buserelin strongly suppressed the activities of thymidylate synthetase and thymidine kinase, and markedly reduced the appearance of BrdU-immunoreactive (S-phase) cells in both prostate glands and uteri in male and female adult rats, respectively.

Asunto(s)

Buserelina/farmacología; ADN/biosíntesis; Próstata/efectos de los fármacos; Útero/efectos de los fármacos; Animales; Peso Corporal/efectos de los fármacos; Estro/fisiología; Femenino; Inmunohistoquímica; Masculino; Tamaño de los Órganos/efectos de los fármacos; Próstata/metabolismo; Ratas; Ratas Sprague-Dawley; Testosterona/sangre; Útero/metabolismo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Próstata / Útero / ADN / Buserelina Límite: Animals Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 1993 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia

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