A genetic familial study of monoamine oxidase B activity and concentration in alcoholics.
Alcohol Clin Exp Res
; 17(2): 263-7, 1993 Apr.
Article
en En
| MEDLINE
| ID: mdl-8488965
Platelet monoamine oxidase B (MAO B) activity and concentration were studied in a small sample of alcoholic families (n = 8) and in 20 unrelated, nonalcoholic controls. Complex segregation analyses of familial data indicated that both activity and concentration are controlled by a single major gene locus with a multifactorial background effect accounting for 0-50% of the variance. When the alcoholic family members (n = 24) were compared with the controls, all determinations of activity display significant differences, whereas MAO B concentration levels showed no difference. These results indicated that the lowered MAO B activities frequently reported among alcoholics do not reflect a change in the number of MAO B macromolecules expressed in platelets, but could be caused by the presence of an inhibitor or by a polymorphic or variant form of the enzyme.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Alcoholismo
/
Isoenzimas
/
Monoaminooxidasa
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Alcohol Clin Exp Res
Año:
1993
Tipo del documento:
Article
Pais de publicación:
Reino Unido