Effect of 15(s)15-methyl-PGF2alpha-methyl ester vaginal suppositories on circulating hormone levels in early pregnancy.
Prostaglandins
; 13(2): 363-73, 1977 Feb.
Article
en En
| MEDLINE
| ID: mdl-847240
ABSTRACT
PIP: 2 uses of prostaglandin analogs (15 methyl PGF2 alpha ester) were studied: effect of vaginal suppositories with the analog on cervical dilation in patients 57-80 days of gestation, and effectiveness of intravaginal use of suppositories containing this analog as a menstrual regulator and early abortifacient. Suppositories containing (each) 1- or 1.5-mg doses of the analog successfully terminated pregnancy of 30-56 days duration in 65-70% of 40 women treated. No significant differences were observed between the 2 dose schedules. In a group of 49 patients studied for the effect of intravaginal administration of PGF2 alpha methyl ester for cervical dilation, cervical dilation of 10 mm or greater was observed after 4 suppositories in all cases. Gastrointestinal side effects were statistically more pronounced in the 1.5-mg vs. 1-mg groups (P.05). Hormonal assays (estradiol-17 beta and progesterone) showed a decline in circulating estradiol-17 beta after vaginal administration of the analog in early pregnancy. Mean levels of 7 cases fell from 2.43 mg/ml-2.1 in 1 hour. These declines were significanly different from pretreatment values (P=.01). Serum progesterone alterations following analog administration were more variable. Whereas the mean level of Estradiol-17 beta fell by 55% after vaginal administration of the abortifacient, mean levels of progesterone fell only 32.7%, mainly because of individual variations. The data indicate a direct action of the analog on the corpus luteum. In addition, the termination of early pregnancy (menstrual regulation) seemed to be caused, partly, by the luteolytic effect of the PGF2 alpha methyl ester as well as by uterine contractions.
Palabras clave
Abortifacient Agents; Abortion, Induced; Biology; Cervix; Clinical Research; Contraception; Contraceptive Methods; Corpus Luteum; Endocrine System; Estradiol--analysis; Estrogens; Family Planning; Fertility Control, Postcoital; Genitalia; Genitalia, Female; Hormones; Menstrual Regulation; Ovary; Physiology; Pregnancy; Pregnancy, First Trimester; Progestational Hormones; Progesterone--analysis; Prostaglandins--administraction and dosage; Reproduction; Research Methodology; Urogenital System; Uterus; Vaginal Spermicides; Vaginal Suppository
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Progesterona
/
Prostaglandinas F
/
Aborto Inducido
/
Estradiol
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Prostaglandins
Año:
1977
Tipo del documento:
Article
Pais de publicación:
Estados Unidos