Involvement of superoxide dismutase and glutathione peroxidase in attenuation of radiation-induced hyperthermia by interleukin-1 alpha in rats.
Brain Res
; 606(1): 106-10, 1993 Mar 19.
Article
en En
| MEDLINE
| ID: mdl-8461990
Pretreatment with recombinant human interleukin-1 alpha (rhIL-1 alpha) 20 h before irradiation attenuates radiation-induced hyperthermia. Experiments were conducted to determine the role of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) in rhIL-1 alpha-induced attenuation of radiation-induced hyperthermia. Radiation exposure increased SOD and decreased GSHPx levels in the hypothalamus, while treatment with rhIL-1 alpha increased GSHPx levels and had no effect on SOD levels. However, rhIL-1 alpha and irradiation together increased hypothalamic SOD level but prevented the fall in GSHPx level. Our results suggest that attenuation of radiation-induced hyperthermia by rhIL-1 alpha may involve stimulation of SOD and GSHPx because rhIL-1 alpha treatment and irradiation together increased hypothalamic GSHPx and SOD levels, and intracerebroventricular administration of SOD and GSHPx attenuated the radiation-induced hyperthermia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Traumatismos Experimentales por Radiación
/
Superóxido Dismutasa
/
Interleucina-1
/
Fiebre
/
Glutatión Peroxidasa
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
1993
Tipo del documento:
Article
Pais de publicación:
Países Bajos