Estrogen receptor variant and hypertension in women.

Lehrer, S; Rabin, J; Kalir, T; Schachter, B S

Lehrer, S; Rabin, J; Kalir, T; Schachter, B S.

Afiliación

Lehrer S; Department of Radiation Therapy, Mount Sinai Medical Center, New York, NY 10029.

Hypertension ; 21(4): 439-41, 1993 Apr.

Article en En | MEDLINE | ID: mdl-8458645

RESUMEN

Eighty-eight women visiting a gynecologist were tested for an estrogen receptor B-variant allele. The women were ethnically and racially homogeneous to a large degree. They were from a suburb of Long Island, and most were white. The 12% incidence of hypertension in women with the estrogen receptor wild-type allele is comparable to the 13-32% incidence in the general population of women aged 55-64 years. However, the 48% incidence of hypertension in women with the estrogen receptor B-variant allele is considerably higher than in the general population of women in this age group. We conclude that the presence of the estrogen receptor B-variant allele might have increased the prevalence of hypertension in the women in this study.

Asunto(s)

Variación Genética; Hipertensión/genética; Receptores de Estrógenos/genética; Factores de Edad; Alelos; Índice de Masa Corporal; Femenino; Humanos; Hipertensión/epidemiología; Hipertensión/metabolismo; Incidencia; Persona de Mediana Edad; Factores Sexuales

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Receptores de Estrógenos / Hipertensión Tipo de estudio: Incidence_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Middle aged Idioma: En Revista: Hypertension Año: 1993 Tipo del documento: Article Pais de publicación: Estados Unidos

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