Effects of early use of captopril on haemodynamics and short-term ventricular remodelling in acute anterior myocardial infarction.
Eur Heart J
; 14(2): 259-66, 1993 Feb.
Article
en En
| MEDLINE
| ID: mdl-8449203
To determine whether ventricular short-term enlargement following acute myocardial infarction is related to increased left filling pressures and whether early treatment with captopril alters this process we studied 68 patients with a first acute myocardial infarction. Forty patients with a pulmonary capillary pressure equal or above 17 mmHg were randomized to treatment with conventional therapy plus captopril (n 20) or placebo (n 20), in a double blind fashion. The remaining 28 patients (non-dysfunction group) were treated conventionally. During the first 72 h, afterload showed a prompt decrease in the captopril group as compared to placebo. Changes from baseline to 14 days in end-diastolic and end-systolic left ventricular volume indexes determined by radionuclide ventriculography were: non-dysfunction, 85.6 (+/- 21) vs 88 (+/- 20) and 44 (+/- 17) vs 44 (+/- 17) ml.m-2; captopril (n 20), 96.6 (+/- 18) vs 99 (+/- 19) and 66 (+/- 22) vs 65 (+/- 22) ml.m-2; placebo (n 20), 96 (+/- 25) vs 113 (+/- 19) (P < 0.001) and 63 (+/- 18) vs 74 (+/- 22) ml.m-2 (P < 0.01). This study indicates that short-term ventricular enlargement is related to the degree of ventricular dysfunction and that captopril may improve this process.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Captopril
/
Hipertrofia Ventricular Izquierda
/
Hemodinámica
/
Infarto del Miocardio
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Eur Heart J
Año:
1993
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Reino Unido