BCG vaccination of full-term infants with chronic intrauterine malnutrition: influence of immunization age on development of post-vaccination, delayed tuberculin hypersensitivity.
Bull World Health Organ
; 71(1): 41-8, 1993.
Article
en En
| MEDLINE
| ID: mdl-8440036
ABSTRACT
PIP: In Brazil, pediatricians followed 109 infants born at the University Hospital of Ribeirao Preto in Sao Paulo every 2 weeks for 3 months and then at 6 months to examine the effect of intrauterine growth retardation (IUGR) on the response to BCG vaccination. They used a tuberculin purified protein derivative to determine tuberculin hypersensitivity and a lymphocyte transformation test to determine lymphocyte proliferation to tuberculin 12-14 weeks after vaccination. The rate of response to BCG in the IUGR infants was basically the same as that of infants whose weight was appropriate for gestational age (AGA) (65% vs. 71%). Specifically, the rate among IUGR infants vaccinated at 5 days old, once they weighed at least 2500 gm (around 26 days old), 3 months old, and 6 months old was 68%, 47%, 69%, and 88%, respectively. The rate among AGA infants vaccinated at 5 days old, 3 months old, and 6 months old was 52%, 90%, and 80%, respectively. The results indicated that BCG vaccination was more immunogenic as the infants aged than when they were newborns, regardless of intrauterine status. They demonstrated that waiting to administer the BCG vaccination when the IUGR infants weighed 2500 gm had no advantage over administering the vaccination when they were newborns. In developing countries with a high prevalence of tuberculosis, such a delay would place these especially vulnerable infants at greater risk of tuberculosis.
Palabras clave
Age Factors; Americas; Biology; Birth Weight; Body Weight; Brazil; Clinical Research; Comparative Studies; Delivery Of Health Care; Demographic Factors; Developing Countries; Diseases; Follow-up Studies; Health; Health Services; Immunity; Immunity, Active; Immunization; Infant; Infections; Latin America; Low Birth Weight; Malnutrition; Nutrition Disorders; Physiology; Population; Population Characteristics; Primary Health Care; Research Methodology; South America; Studies; Tuberculosis; Vaccination--side effects; Youth
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Vacuna BCG
/
Retardo del Crecimiento Fetal
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Newborn
Idioma:
En
Revista:
Bull World Health Organ
Año:
1993
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Suiza