Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth.
Cancer Res
; 53(4): 851-6, 1993 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-8428365
The mouse PM-1 monoclonal antibody binds to the human interleukin 6 receptor, inhibits IL-6 functions, and shows strong antitumor cell activity against multiple myeloma cells. In order to be effective as a therapeutic agent administered to human patients in repeated doses, reshaped human PM-1 antibodies consisting of human REI-based light chain and NEW-based heavy chain variable regions were designed and constructed with the assistance of a structural model of the mouse PM-1 variable regions. The best reshaped human PM-1 antibody is equivalent to mouse or chimeric PM-1 antibody in terms of antigen binding and growth inhibition against multiple myeloma cells. Only a few minor changes in the human framework regions were required to recreate the mouse PM-1 antigen-binding site within a human antibody. The reshaped human PM-1 antibody, therefore, could be efficacious in human multiple myeloma patients.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Región Variable de Inmunoglobulina
/
Receptores Inmunológicos
/
Interleucina-6
/
Cadenas Pesadas de Inmunoglobulina
/
Cadenas Ligeras de Inmunoglobulina
/
Anticuerpos Monoclonales
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Res
Año:
1993
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos