Early cytokine response to multiple injury.

Foëx, B A; Lamb, W R; Roberts, T E; Brear, S G; Macartney, I; Hammer, M; Brenchley, P E

Foëx, B A; Lamb, W R; Roberts, T E; Brear, S G; Macartney, I; Hammer, M; Brenchley, P E.

Afiliación

Foëx BA; Department of Intensive Care, North Manchester General Hospital, UK.

Injury ; 24(6): 373-6, 1993 Jul.

Article en En | MEDLINE | ID: mdl-8406740

RESUMEN

Serial measurements of the inflammatory cytokines interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF alpha) were made in four patients with multiple injuries to characterize secretion patterns and to relate them to severity of injury and degree of haemorrhage. IL-6 and TNF alpha were assayed using a sandwich ELISA. Injury scores varied from 9 to 50, and transfusion requirements varied from 7 to 14 units. All patients showed an increase in IL-6 but only one a rise in TNF alpha. There was no consistent pattern in the elevation of IL-6 and there was no relation between cytokine levels, severity of injury, transfusion requirement or ultimate outcome. From this preliminary study it would seem that measurement of IL-6 and TNF alpha is not of value in directing therapeutic decisions or as a predictor of outcome.

Asunto(s)

Interleucina-6/metabolismo; Traumatismo Múltiple/inmunología; Factor de Necrosis Tumoral alfa/metabolismo; Adulto; Anciano; Anciano de 80 o más Años; Femenino; Humanos; Puntaje de Gravedad del Traumatismo; Masculino; Traumatismo Múltiple/sangre; Intento de Suicidio; Factores de Tiempo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismo Múltiple / Interleucina-6 / Factor de Necrosis Tumoral alfa Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Injury Año: 1993 Tipo del documento: Article Pais de publicación: Países Bajos

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