Disrupted beta 1-adrenoceptor-G protein coupling in the temporal cortex of patients with Alzheimer's disease.
Neurosci Lett
; 155(2): 163-6, 1993 Jun 11.
Article
en En
| MEDLINE
| ID: mdl-8397350
The efficacy of beta 1-adrenoceptor-G protein coupling was studied in postmortem temporal cortex synaptic membranes from a series of control and Alzheimer's disease subjects. For the control cases, the non-hydrolysable GTP analogue 5'-guanylylimidodiphosphate (Gpp[NH]p) gave a significant reduction in the affinity of the agonist isoprenaline to displace binding of the radiolabelled antagonist (+/)-4-(3-t-butylamino-2-hydroxypropoxy)[5,7-3H]benzimidazol-2-one ([3H]CGP-12177). This effect was attributed to the conversion of high agonist-affinity sites to a lower-affinity state and was not found for the Alzheimer's disease cases. These data indicate that a disruption of beta 1-adrenoceptor-G protein coupling occurs in the temporal cortex of Alzheimer's disease patients.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Membranas Sinápticas
/
Lóbulo Temporal
/
Receptores Adrenérgicos beta
/
Proteínas de Unión al GTP
/
Enfermedad de Alzheimer
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurosci Lett
Año:
1993
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Irlanda