Antibody-mediated suppression of tumor growth. III. Molecular assay of murine IgG1 alloantibody required to cause tumor suppression in vivo.
J Immunol
; 118(2): 498-504, 1977 Feb.
Article
en En
| MEDLINE
| ID: mdl-839068
A radioimmunoassay was used to quantitate the number of tumor cell-bound IgG1 anti-tumor antibody molecules required to cause suppression of tumor growth in C3H mice. Radiolabeled anti-IgG1 was used to detect cell-bound IgG1 antibody. The assay was calibrated by using TNP-coupled tumor cells that had a known number of bound IgG1 anti DNP molecules. Between 70,000 and 130,000 IgG1 anti-tumor antibody molecules per tumor cell were sufficient to cause 50% suppression of tumor growth in mice inoculated with appriximately 50,000 tumor cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunoglobulina G
/
Transformación Celular Neoplásica
/
Inmunosupresores
/
Isoanticuerpos
/
Anticuerpos Antineoplásicos
/
Especificidad de Anticuerpos
Límite:
Animals
Idioma:
En
Revista:
J Immunol
Año:
1977
Tipo del documento:
Article
Pais de publicación:
Estados Unidos