Wilms tumor in a patient with Prader-Willi syndrome.

Coppes, M J; Sohl, H; Teshima, I E; Mutirangura, A; Ledbetter, D H; Weksberg, R

Coppes, M J; Sohl, H; Teshima, I E; Mutirangura, A; Ledbetter, D H; Weksberg, R.

Afiliación

Coppes MJ; Department of Cancer Biology, Cleveland Clinic Foundation, Ohio.

J Pediatr ; 122(5 Pt 1): 730-3, 1993 May.

Article en En | MEDLINE | ID: mdl-8388447

RESUMEN

The development of Wilms tumor in a patient with Prader-Willi syndrome prompted us to determine the parental origin of the genes implicated in both disorders because of the sex-specific parent-of-origin effects previously demonstrated for both conditions. A paternal chromosome 15q11-q13 deletion was demonstrated, but no changes were demonstrated in a limited analysis of chromosome 11p, which harbors two Wilms tumor suppressor genes, WT1 and WT2.

Asunto(s)

Neoplasias Renales/genética; Síndrome de Prader-Willi/genética; Tumor de Wilms/genética; Deleción Cromosómica; Cromosomas Humanos Par 11; Humanos; Lactante; Neoplasias Renales/complicaciones; Masculino; Síndrome de Prader-Willi/complicaciones; Tumor de Wilms/complicaciones

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Prader-Willi / Tumor de Wilms / Neoplasias Renales Límite: Humans / Infant / Male Idioma: En Revista: J Pediatr Año: 1993 Tipo del documento: Article Pais de publicación: Estados Unidos

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