PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene.
Biochem Biophys Res Commun
; 192(1): 37-45, 1993 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-8386511
A DNA sequence that confers a response to a class of rodent hepatocarcinogens termed peroxisome proliferators has been identified 2947bp upstream of the rat peroxisomal bifunctional enzyme gene. Two members of the steroid hormone receptor family, termed the peroxisome proliferator activated receptor (PPAR alpha) and the retinoid X receptor (RXR alpha), co-operate to bind specifically to this sequence. Importantly, this response element (PPRE) is similar to that identified upstream of other peroxisome proliferator responsive genes such as those encoding acyl CoA oxidase and cytochrome P450 IVA6. These data therefore provide further evidence that PPAR alpha plays an important role in mediating the action of peroxisome proliferators.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Proteínas Nucleares
/
Secuencias Reguladoras de Ácidos Nucleicos
/
Receptores de Ácido Retinoico
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Receptores Citoplasmáticos y Nucleares
/
Receptores de Superficie Celular
/
Enoil-CoA Hidratasa
/
3-Hidroxiacil-CoA Deshidrogenasas
/
Isomerasas
/
Complejos Multienzimáticos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
1993
Tipo del documento:
Article
Pais de publicación:
Estados Unidos