Hepatocellular carcinoma producing universal type of alkaline phosphatase.
Dig Dis Sci
; 38(4): 757-61, 1993 Apr.
Article
en En
| MEDLINE
| ID: mdl-8384982
We report on a 54-year-old man with hepatocellular carcinoma (HCC) associated with a marked elevation of serum alkaline phosphatase (ALP) levels. Serum ALP was biochemically similar to that of universal (liver/bone/kidney) type. The noncarcinomatous area revealed typical micronodular cirrhosis due to excessive alcohol consumption. By histochemical staining, ALP activity was demonstrated diffusely within the cytoplasm of carcinoma cells. Immunohistochemical observation of the carcinoma cells excluded the intestinal or placental type of ALP. Tissue extracts from the carcinomatous area had much higher ALP activities than those from a noncarcinomatous area, which also showed characteristics of the universal type. The present HCC is the first reported to produce and excrete the universal type of ALP.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinoma Hepatocelular
/
Fosfatasa Alcalina
/
Pruebas Enzimáticas Clínicas
/
Neoplasias Hepáticas
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Dig Dis Sci
Año:
1993
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos