Polyene antibiotics inhibit superoxide-producing NADPH oxidase in a polymorphonuclear cell-free system.
Biochem Pharmacol
; 45(3): 766-8, 1993 Feb 09.
Article
en En
| MEDLINE
| ID: mdl-8382922
We studied the effect of polyene macrolide antibiotics on the NADPH-dependent superoxide production induced by arachidonic acid in a cell-free system consisting of the membrane and cytosolic fractions obtained from bovine polymorphonuclear leukocytes. Preincubation of the membrane fraction with polyenes before addition of the soluble components of the reaction mixture resulted in a dose-dependent inhibition of superoxide production.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polienos
/
Superóxidos
/
Antibacterianos
/
NADH NADPH Oxidorreductasas
/
Neutrófilos
Límite:
Animals
Idioma:
En
Revista:
Biochem Pharmacol
Año:
1993
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Reino Unido