The use of internalizable derivatives of chlorin E6 for increasing its photosensitizing activity.

Akhlynina, T V; Rosenkranz, A A; Jans, D A; Gulak, P V; Serebryakova, N V; Sobolev, A S

Akhlynina, T V; Rosenkranz, A A; Jans, D A; Gulak, P V; Serebryakova, N V; Sobolev, A S.

Afiliación

Akhlynina TV; Russian Research Center of Molecular Diagnostics and Therapy, Moscow.

Photochem Photobiol ; 58(1): 45-8, 1993 Jul.

Article en En | MEDLINE | ID: mdl-8378431

RESUMEN

Experiments with human hepatoma PLC/PRF/5 cells and human embryo skin fibroblasts involving the use of three different tests (colony formation, Trypan blue exclusion, labeled thymidine incorporation) have demonstrated a significantly higher photosensitizing activity of chlorin e6 conjugates with internalizable ligands as compared to that of chlorin e6 itself. Receptor-mediated internalization of chlorin e6 conjugates ensures a greater photosensitization of cells than binding of those conjugates to cell surface receptors. The suitability of such conjugates that permit the delivery of a photosensitizer to sensitive intracellular targets is discussed.

Asunto(s)

Fármacos Fotosensibilizantes/farmacología; Porfirinas/farmacología; Células Cultivadas; Clorofilidas; Fibroblastos/efectos de los fármacos; Fibroblastos/efectos de la radiación; Humanos; Fotoquímica; Fotoquimioterapia; Fármacos Fotosensibilizantes/metabolismo; Porfirinas/metabolismo; Receptor de Insulina/metabolismo; Células Tumorales Cultivadas/efectos de los fármacos; Células Tumorales Cultivadas/efectos de la radiación

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Porfirinas / Fármacos Fotosensibilizantes Límite: Humans Idioma: En Revista: Photochem Photobiol Año: 1993 Tipo del documento: Article Pais de publicación: Estados Unidos

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