Column liquid chromatographic analysis of quinine in human plasma, saliva and urine.

Babalola, C P; Bolaji, O O; Dixon, P A; Ogunbona, F A

Babalola, C P; Bolaji, O O; Dixon, P A; Ogunbona, F A.

Afiliación

Babalola CP; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.

J Chromatogr ; 616(1): 151-4, 1993 Jun 23.

Article en En | MEDLINE | ID: mdl-8376486

RESUMEN

A new simple, selective and reproducible high-performance liquid chromatographic method for the determination of quinine in plasma, saliva and urine is described. The ion-pair method was carried out on a reversed-phase C18 column, using perchlorate ion as the counter ion and ultraviolet detection at 254 nm. Quinine was well resolved from its major metabolite, 3-hydroxyquinine, and the internal standard, primaquine. The limit of detection was 10 ng/ml and the recovery was greater than 90% from the three biological fluids.

Asunto(s)

Quinina/análisis; Saliva/química; Cromatografía Líquida de Alta Presión; Humanos; Indicadores y Reactivos; Primaquina/análisis; Primaquina/sangre; Primaquina/orina; Quinidina/análogos & derivados; Quinidina/análisis; Quinidina/sangre; Quinidina/orina; Quinina/sangre; Quinina/orina; Espectrofotometría Ultravioleta

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinina / Saliva Límite: Humans Idioma: En Revista: J Chromatogr Año: 1993 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Países Bajos

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