The human endogenous retrovirus ERV-3 is upregulated in differentiating placental trophoblast cells.
Virology
; 196(2): 905-9, 1993 Oct.
Article
en En
| MEDLINE
| ID: mdl-8372456
The single copy endogenous retrovirus locus ERV-3 is known to be primarily expressed in the placenta. The absence of expression of this gene in choriocarcinoma cell lines has led to speculation that this may be a defect associated with this abnormality. We show here that ERV-3 is not normally expressed in the cytotrophoblast from which these tumour cells are derived but is expressed in normal syncytiotrophoblast. The conservation of the ERV-3 open reading frame for env in ape and old world monkey species and its tight regulation and site of expression suggest a functional role for this gene in this tissue.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Retroviridae
/
Trofoblastos
/
Regulación hacia Arriba
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Virology
Año:
1993
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
Estados Unidos