Regulation of the transcription factor c-JUN by nerve growth factor in adult sensory neurons.
Neurosci Lett
; 154(1-2): 129-33, 1993 May 14.
Article
en En
| MEDLINE
| ID: mdl-8361625
We examined the regulation by nerve growth factor (NGF) of the immediate-early gene (proto-oncogene) c-jun in adult dorsal root ganglion (DRG) neurons using immunocytochemistry to c-JUN (the protein product of the proto-oncogene c-jun). Following a sciatic nerve crush, the injury-induced increase in c-JUN-like immunostaining was reduced in DRG neurons by continuous intrathecal infusion of NGF for one week. Conversely, in intact DRG neurons (i.e., without Wallerian degeneration), c-JUN-like immunoreactivity was markedly increased following four weeks of daily NGF antiserum injections (to remove target tissue-derived NGF) into the hindfoot. Taken together, these findings indicate that nerve transection (axotomy) results in a loss of target tissue-derived NGF leading to induction of the transcription factor c-jun which may play a role in axonal regeneration.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
/
Genes jun
/
Factores de Crecimiento Nervioso
/
Neuronas Aferentes
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
1993
Tipo del documento:
Article
Pais de publicación:
Irlanda